Simparica TRIO
Simparica TRIO for Dogs

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Dog Supplies >> Flea & Tick 2026-05-16

Simparica TRIO for Dogs

481 PROD-481
By: Zoetis
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Simparica Trio Chewables for Dogs

Simparica Trio Chewable is designed to provide broad-spectrum protection against common internal and external parasites in dogs. Available as a palatable, simple-to-give chewable, Simparica Trio offers protection against heartworm disease, ticks and fleas, and intestinal worms.

What Simparica Trio covers

  • Kills fleas and prevents flea infestations
  • Kills 6 types of ticks
  • Gulf Coast ticks
  • Black-legged ticks or deer ticks
  • Brown dog ticks
  • American dog ticks
  • Lone star tick
  • Asian longhorned ticks
  • Treats and controls roundworms and hookworms
  • Helps prevent flea tapeworms by killing fleas
  • Helps prevent heartworm disease in dogs

How Simparica Trio works

Simparica Trio’s triple-action protection is powered by sarolaner, moxidectin, and pyrantel. Sarolaner kills fleas and ticks by affecting their neuromuscular activity. Moxidectin helps prevent heartworm disease by targeting heartworm larvae. The third ingredient, pyrantel, is a nematocide that treats and controls intestinal worms like roundworms and hookworms.

Who Simparica Trio is for

Simparica Trio for Dogs is suitable for dogs and puppies from 8 weeks of age and older, weighing at least 2.8 lbs.

Why Choose Simparica Trio for Dogs

  • Broad-spectrum parasite prevention

    Simparica Trio combines protection for fleas, ticks, heartworm disease, and intestinal worms in a single monthly treatment, eliminating the need for multiple products.

  • Simple and easy administration

    Simparica Trio for Dogs is available as a tasty chew to entice all dogs to take the treatment without fuss, making the administration simple and hassle-free.

  • Fast-acting formulation

    Simparica Trio begins killing fleas in just 4 hours of administration and deer ticks within 8 hours of administration. It has been shown to kill adult fleas within 24 hours of administration.

Protect your dog from nasty parasites like fleas, ticks, and worms with Simparica Trio for Dogs.

  • Weigh your dog before starting the treatment to ensure dosage accuracy.
  • Remove only one chewable at a time from the pack.
  • Administer orally once a month as directed.
  • Offer the chewable either directly or by mixing with food.
  • Ensure the full dose is consumed, and if a dose is lost or rejected, redosing is recommended.
  • For optimal parasite control, treat your dog on or about the same day each month.

Simparica Trio Dosage for Dogs:

Dog’s Weight (lbs) Sarolaner per Tablet (mg) Moxidectin per Tablet (mg) Pyrantel per Tablet (mg) Number of Chews Per Month
2.8 – 5.55 3 0.06 12.5 One
5.6 – 11 6 0.12 25 One
11.1 – 22 12 0.24 50 One
22.1 – 44 24 0.48 100 One
44.1 – 88 48 0.96 200 One
88.1 – 132 72 1.44 300 One
> 132 Administer the appropriate combination of tablets

For dogs over 132 lbs, administer the appropriate combination of Simparica Trio Chewables.

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Simparica TRIO

Simparica TRIO

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Full Coverage

Covers multiple concerns at once. Gives me real peace of mind.

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Pet Ease

My dog seems more relaxed and comfortable now.

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